氧化应激和自噬在动脉粥样硬化中的作用研究新进展
发布时间：2019-02-20 08:25
【摘要】：动脉粥样硬化是一种累及全身大、中动脉的多因素、多步骤失调性病变,是各种心脑血管疾病的病理基础。动脉粥样硬化的发病机制目前仍不完全清楚。近年来国内外越来越多的证据表明,氧化应激和自噬是动脉粥样硬化形成和发展的关键因素。氧化应激通过直接氧化损伤和间接信号介导损伤促进了动脉粥样硬化的发生发展;自噬具有抗动脉粥样硬化和促动脉粥样硬化的双重作用;二者又有错综复杂的交联关系。本文分别从氧化应激在动脉粥样硬化中的作用、自噬在动脉粥样硬化中的作用、氧化应激和自噬在动脉粥样硬化中的交联作用三方面展开论述,为疾病的认识和治疗提供新思路。
[Abstract]:Atherosclerosis is a kind of multifactor and multistep maladjustment disease involving the whole body and middle artery, which is the pathological basis of various cardiovascular and cerebrovascular diseases. The pathogenesis of atherosclerosis is still unclear. In recent years, there is more and more evidence at home and abroad that oxidative stress and autophagy are the key factors in the formation and development of atherosclerosis. Oxidative stress promotes the occurrence and development of atherosclerosis through direct oxidative injury and indirect signaling injury. Autophagy has the dual effects of anti-atherosclerosis and promoting atherosclerosis. This paper discusses the role of oxidative stress in atherosclerosis, the role of autophagy in atherosclerosis, and the cross-linking of oxidative stress and autophagy in atherosclerosis. To provide new ideas for the understanding and treatment of diseases.
【作者单位】： 天津中医药大学研究生院;天津中医药大学第一附属医院心内科;
【基金】：国家自然科学基金资助项目(81403217) 高等学校博士学科点专项科研基金(20121210110002)
【分类号】：R543.5
[Abstract]:Atherosclerosis is a kind of multifactor and multistep maladjustment disease involving the whole body and middle artery, which is the pathological basis of various cardiovascular and cerebrovascular diseases. The pathogenesis of atherosclerosis is still unclear. In recent years, there is more and more evidence at home and abroad that oxidative stress and autophagy are the key factors in the formation and development of atherosclerosis. Oxidative stress promotes the occurrence and development of atherosclerosis through direct oxidative injury and indirect signaling injury. Autophagy has the dual effects of anti-atherosclerosis and promoting atherosclerosis. This paper discusses the role of oxidative stress in atherosclerosis, the role of autophagy in atherosclerosis, and the cross-linking of oxidative stress and autophagy in atherosclerosis. To provide new ideas for the understanding and treatment of diseases.
【作者单位】： 天津中医药大学研究生院;天津中医药大学第一附属医院心内科;
【基金】：国家自然科学基金资助项目(81403217) 高等学校博士学科点专项科研基金(20121210110002)
【分类号】：R543.5
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2 张刘锋;;氧化应激与心血管疾病的新进展(续前)[J];中华高血压杂志;2010年02期
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