振源胶囊辅助治疗慢性心力衰竭有效性比较的Meta分析

发布时间：2019-02-26 11:29

【摘要】：计算机检索Pub Med,EMbase,the Cochrane Library,CBM,CNKI,VIP,Wanfang Data数据库,收集振源胶囊辅助治疗慢性心力衰竭的相关随机对照试验(RCT),检索时间限制从建库至2016年10月。由2位评价者独立筛选文献、提取资料和评价纳入文献的偏倚风险后,采用Rev Man 5.3软件进行Meta分析,系统评价振源胶囊对慢性心力衰竭病人疗效。最终纳入14个RCT,共1 204例慢性心力衰竭患者。Meta分析结果显示,振源胶囊组的心功能疗效[RR=1.27,95%CI(1.20,1.35),P0.000 01],每搏输出量[WMD=7.62,95%CI(6.39,8.84),P0.000 01],HAMA评分[WMD=-4.16,95%CI(-5.59,-2.72),P0.000 01],HAMA心理疗效[RR=1.47,95%CI(1.15,1.89),P=0.002],中医症候疗效[RR=1.46,95%CI(1.25,1.72),P0.000 01]均显著优于对照组,且差异具有统计学意义。现有证据表明,在常规西药治疗基础上联用振源胶囊可以改善慢性心力衰竭患者心功能、心理状态,提高生活质量,且安全性好。受纳入研究质量和数量的限制,仍需大规模高质量RCT予以验证。
[Abstract]:A computer search of Pub Med,EMbase,the Cochrane Library,CBM,CNKI,VIP,Wanfang Data database was conducted to collect the (RCT), search time limit for randomized controlled trials of Zhenyuan capsule in the treatment of chronic heart failure (CHF) from the establishment of the database to October 2016. After selecting the literature independently by two evaluators, extracting the data and evaluating the bias risk of inclusion in the literature, Meta analysis was carried out with Rev Man 5.3 software to systematically evaluate the curative effect of Zhenyuan capsule on patients with chronic heart failure. Fourteen RCT, patients with chronic heart failure were included in the study. Meta-analysis showed that the heart function of Zhenyuan capsule group was effective [RR=1.27,95%CI (1.20, 1.35), P0.000 01], Stroke volume [WMD=7.62,95%CI (6.39, 8.84), P0.000 01], HAMA score [WMD=-4.16,95%CI (- 5.59, 2.72), P0.000 01], psychological efficacy of HAMA [RR=1.47,95%CI (1.15, 1.89), RR=1.46,95%CI (1.25, 1.72), P0.000 01) were significantly better than those in the control group (P < 0.05), and there was significant difference between the two groups (P < 0.05). Existing evidence shows that combined with Zhenyuan capsule on the basis of conventional western medicine can improve the heart function, mental state, quality of life and safety of patients with chronic heart failure. Limited by the quality and quantity of inclusion studies, large-scale high-quality RCT still needs to be verified.
【作者单位】：华中科技大学同济医学院附属同济医院心内科;
【基金】：国家自然科学基金项目(81270353)
【分类号】：R541.6

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