伊伐布雷定联合比索洛尔对冠心病PCI术后患者心脏康复的影响

发布时间：2019-07-19 17:16

【摘要】：目的:研究伊伐布雷定联合比索洛尔对冠心病经皮冠状动脉介入(PCI)术后患者心脏康复的影响。方法:选取于某院行PCI术的冠心病患者84例,随机分为观察组(n=42)及对照组(n=42),观察组在常规冠心病二级预防治疗的基础上给予比索洛尔1.25 mg联合伊伐布雷定治疗,对照组在常规冠心病二级预防治疗的基础上仅给予比索洛尔5~10 mg口服。分别于治疗前、治疗4周及治疗12周时监测两组患者的6 min步行实验的距离、6 min步行实验的心率及血氧饱和度、左室射血分数、左室收缩末期内径、左室舒张末期内径、左室间隔厚度及左心室壁厚度。结果:观察组与对照组比较,在治疗12周时,6min步行试验的距离、LVEF及左室正常舒张功能的比例明显增加,LVEDD、LVESD及6 min步行实验时的心室率明显降低,差异均具有统计学意义(P0.05);与治疗前相比,在治疗4周及12周时,观察组的6 min步行试验的距离、LVEF及左室正常舒张功能的比例明显增加,LVEDD、LVESD及6 min步行实验时的心室率明显降低,差异均具有统计学意义(P0.05);研究期间,观察组不良反应发生率低于对照组,但无统计学差异(P0.05)。结论:伊伐布雷定联合比索洛尔对冠心病PCI术后患者的心脏康复的长期效果优于单纯比索洛尔治疗,不增加不良反应,是一种安全有效的治疗方案。
[Abstract]:Objective: To study the effect of ivabradine and bisoprolol on the heart recovery of patients with coronary heart disease after percutaneous coronary intervention (PCI). Methods:84 patients with coronary heart disease were randomly divided into observation group (n = 42) and control group (n = 42). The control group only given bisoprolol 5-10mg for oral administration on the basis of routine secondary prevention and treatment of coronary heart disease. The 6-min walking distance, the heart rate and the blood oxygen saturation, the left ventricular ejection fraction, the left ventricular end-diastolic diameter, the left ventricular end-diastolic diameter, the left ventricular septum thickness and the left ventricular wall thickness of the two groups were monitored at 4 weeks and 12 weeks prior to treatment, respectively. Results: Compared with the control group, the ratio of LVEF and left ventricular diastolic function was significantly increased at 12 weeks and 6 min, and the ventricular rate in LVEDD, LVESD and 6 min walking experiment was significantly decreased, and the difference was statistically significant (P <0.05); in comparison with the pre-treatment, After 4 and 12 weeks of treatment, the distance between the 6-min walking test of the observation group, the ratio of the LVEF and the normal diastolic function of the left ventricle were significantly increased, and the ventricular rate of the LVEDD, LVESD and the 6-minute walking experiment was significantly reduced, and the difference was statistically significant (P0.05); and during the study, The incidence of adverse reactions in the observation group was lower than that of the control group, but there was no statistical difference (P0.05). Conclusion: The long-term effect of ivabradine and bisoprolol on the heart recovery of patients with coronary heart disease after PCI is superior to that of pure Bisoprolol.
【作者单位】：北京大学人民医院;江汉大学附属医院;
【分类号】：R541.4

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