老年血压正常高值者单核细胞趋化蛋白-1、氧化低密度脂蛋白胆固醇与动脉粥样硬化的相关性
发布时间：2019-08-07 15:29
【摘要】：目的通过对血清单核细胞趋化蛋白(MCP)-1、氧化低密度脂蛋白胆固醇(ox-LDL)、超敏C反应蛋白(hs-CRP)、一氧化氮(NO)等分子水平变化的研究,探讨老年血压正常高值者与动脉粥样硬化(AS)发病机制的关系。方法按血压水平选取老年正常血压者、血压正常高值者各80例。酶联免疫吸附法测定血清MCP-1、ox-LDL的浓度,硝酸还原酶法测定NO水平,用散射比浊法测血清中hs-CRP含量,并检测血脂等相关生化指标。结果老年血压正常高值组MCP-1、ox-LDL、hs-CRP、TC、合并AS发生率均高于正常血压组,NO、HDL低于正常血压组(P0.05或P0.01);血压正常高值组甘油三酯(TG)、低密度脂蛋白(LDL)、极低密度脂蛋白(VLDL)高于正常血压组但无统计学意义(P0.05);MCP-1与oxLDL、TC、hs-CRP呈正相关(r=0.31,0.28,0.29 P0.01),与NO、HDL呈负相关(r=-0.25,-0.30,P0.01或P0.05)。结论老年血压正常高值组合并AS发生率提高,病变程度可能和血压升高引起的MCP-1的增加及ox-LDL的大量产生密切相关。
[Abstract]:Objective to investigate the relationship between the pathogenesis of atherosclerotic (AS) and the changes of serum monocyte chemotactic protein (MCP)-1, oxidized low density lipoprotein cholesterol (ox-LDL), high sensitive C-reactive protein (hs-CRP) and nitric oxide (NO). Methods 80 elderly patients with normal blood pressure and 80 patients with high blood pressure were selected according to the level of blood pressure. The concentration of serum MCP-1,ox-LDL was measured by enzyme-linked immunosorbent assay (Elisa), the level of NO was measured by nitrate reductase method, the content of hs-CRP in serum was measured by turbidimetry, and the related biochemical indexes such as blood lipid were detected. Results the incidence of MCP-1,ox-LDL,hs-CRP,TC, with AS in the group with normal blood pressure was higher than that in the group with normal blood pressure, and the incidence of NO,HDL in the group with normal blood pressure was lower than that in the group with normal blood pressure (P 0.05 or P 0.01). The incidence of AS in the group with normal blood pressure was higher than that in the group with normal blood pressure (P < 0.05), but there was no significant difference between the two groups (P < 0.05). MCP-1 was positively correlated with oxLDL,TC,hs-CRP (r 鈮，
本文编号：2524033
[Abstract]:Objective to investigate the relationship between the pathogenesis of atherosclerotic (AS) and the changes of serum monocyte chemotactic protein (MCP)-1, oxidized low density lipoprotein cholesterol (ox-LDL), high sensitive C-reactive protein (hs-CRP) and nitric oxide (NO). Methods 80 elderly patients with normal blood pressure and 80 patients with high blood pressure were selected according to the level of blood pressure. The concentration of serum MCP-1,ox-LDL was measured by enzyme-linked immunosorbent assay (Elisa), the level of NO was measured by nitrate reductase method, the content of hs-CRP in serum was measured by turbidimetry, and the related biochemical indexes such as blood lipid were detected. Results the incidence of MCP-1,ox-LDL,hs-CRP,TC, with AS in the group with normal blood pressure was higher than that in the group with normal blood pressure, and the incidence of NO,HDL in the group with normal blood pressure was lower than that in the group with normal blood pressure (P 0.05 or P 0.01). The incidence of AS in the group with normal blood pressure was higher than that in the group with normal blood pressure (P < 0.05), but there was no significant difference between the two groups (P < 0.05). MCP-1 was positively correlated with oxLDL,TC,hs-CRP (r 鈮，
本文编号：2524033
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