盐酸异丙肾上腺素致犬慢性心肌缺血模型的制备

发布时间：2017-12-30 19:32

本文关键词：盐酸异丙肾上腺素致犬慢性心肌缺血模型的制备　出处：《中国兽医学报》2015年12期 　论文类型：期刊论文

【摘要】：为制备盐酸异丙肾上腺素致犬慢性心肌缺血模型,将12只比格犬随机分为空白组及模型组,模型组犬按1.1 mg/kg剂量皮下注射盐酸异丙肾上腺素,空白组犬给予相应的生理盐水,于试验后不同时间检测血压、心率及心电图的改变。结果显示,与空白组犬相比,模型组犬血压降低(P0.01或P0.05),心率加快(P0.01或P0.05),ST段抬高(P0.01或P0.05);表明盐酸异丙肾上腺素诱导犬慢性心肌缺血模型成功建立。
[Abstract]:In order to establish a canine model of chronic myocardial ischemia induced by isoproterenol hydrochloride, 12 Beagle dogs were randomly divided into blank group and model group. The dogs in the model group were subcutaneously injected with isoproterenol hydrochloride at the dose of 1.1 mg/kg. The dogs in blank group were given normal saline and the changes of blood pressure heart rate and electrocardiogram were detected at different time after the experiment. The results showed that compared with the blank group. In the model group, the blood pressure decreased P0.01 or P0.05A, and the heart rate accelerated P0.01 or P0.05 St segment elevation (P0.01 or P0.05). The results showed that the canine model of chronic myocardial ischemia induced by isoproterenol hydrochloride was successfully established.
【作者单位】：辽宁省中医药研究院;
【基金】：国家科技部中药新药临床评价研究技术平台建设子课题资助项目(2012ZX09303-017-001-02)
【分类号】：R542.2;R-332
【正文快照】： *Corresponding author,E-mail:syyljdgx024@126.com近年来,心肌缺血性疾病严重威胁着人类的健康,如心律失常、心肌梗死、冠心病等。其发生率和死亡率呈逐年上升趋势,严重影响着患者的生命安全,因此,在医学界引起了广泛重视。随着对心肌缺血性疾病研究的深入,该类疾病的动物实

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