活菌制剂冻干保护剂的研究进展

发布时间：2018-01-10 17:09

本文关键词：活菌制剂冻干保护剂的研究进展　出处：《微生物学免疫学进展》2015年04期 　论文类型：期刊论文

【摘要】：冷冻干燥技术广泛应用于细菌性活疫苗生产和菌种保藏等方面。细菌细胞在冷冻干燥过程中会出现损伤,甚至死亡。通过添加适合的冻干保护剂可以最大程度减小细胞损伤,保持活菌制剂的活力和性能。就冻干过程对细菌的损伤机制、冻干保护剂的作用机理以及保护剂的筛选方法等方面进行了阐述,对活菌制剂保护剂的筛选有所启示。
[Abstract]:Freeze-drying technology is widely used in the production of live bacterial vaccines and the preservation of bacterial species. Bacterial cells will be damaged during freeze-drying. Even death. By adding suitable lyophilized protectants to minimize cell damage, to maintain the vitality and performance of live bacteriological agents. On the lyophilization process of bacteria damage mechanism. The mechanism of lyophilized protectants and the screening methods of protective agents were expounded, and some enlightenment to the screening of protective agents for living-bacteria preparations was given.
【作者单位】：兰州生物制品研究所有限责任公司甘肃省疫苗工程技术研究中心;
【分类号】：R392
【正文快照】： 冷冻干燥(Freeze drying)就是将含水的物质预先降温冻结成固体,然后在低温减压条件下利用水的升华性能,使物质低温脱水而达到干燥目的的一种干燥方法。冷冻干燥技术与其他干燥方法相比突出的优点在于:1制品在低温下干燥,各种成分活性丧失少;2冻结时制品可形成一定的形态,在干

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