嗅小球电生理网络建模及平台期型球周围细胞功能研究

发布时间：2018-01-13 08:31

本文关键词：嗅小球电生理网络建模及平台期型球周围细胞功能研究　出处：《浙江大学》2013年硕士论文　论文类型：学位论文

【摘要】：在嗅觉系统中,嗅球是嗅觉信息在大量传送到各种次级结构之前的最后处理阶段,是对嗅觉信息进行整合和编码的重要部位,因而对嗅球电生理的研究是了解嗅觉系统信息编码机制的基础。嗅球上的嗅小球中包含很多对嗅觉信息输入执行多种、不同操作的复杂微网络,在嗅觉信息处理中起着重要的作用。球周围细胞是参与嗅小球回路的重要中间神经元,它们在嗅觉信息处理中所起的功能还有待研究。球周围细胞存在很多亚类,不同亚类在功能上也存在差异,其中一个亚类在刺激下发放平台期电位。平台期电位型球周围细胞具有能够将嗅感觉神经元轴突的高频输入转化为低频输出的特性,很有可能参与了调控嗅小球活动的时序模式,这类细胞正逐步引起人们的注意。本论文建立了一个包含平台期型球周围细胞、僧帽细胞及细胞间突触联结的嗅小球网络模型,为研究嗅小球回路在嗅觉信息编码中的作用提供研究平台,并初步分析发放平台期电位的球周围细胞在嗅小球网络中的作用。本论文首先简要介绍了嗅觉产生机理与嗅球解剖结构,详细介绍了嗅小球及其模型研究现状,并对球周围细胞的生理特性及其建模进展进行了介绍；其次,详细介绍了建立的嗅小球网络模型所采用的神经元电缆模型、离子通道动力学模型、神经突触动力学模型以及建模工具软件；再次,介绍了网络模型中加入的各类细胞模型以及各类突触模型的参数设置,并对网络的拓扑结构进行了介绍；最后,在网络模型的基础上,初步分析研究了平台期型球周围细胞的作用,发现平台期型球周围细胞对投射到同一个嗅小球中的僧帽细胞的峰值发放同步有作用。本论文建立的嗅小球电生理网络模型为嗅觉神经系统编码的理论研究提供了一个良好的平台,同时本论文的研究结果,为下一步对嗅觉神经系统编码理论的深入研究打下了良好的基础。
[Abstract]:In olfactory system, olfactory bulb is the final processing stage of olfactory information before it is transferred to various secondary structures, and it is an important part of olfactory information integration and coding. Therefore, the study of olfactory bulb electrophysiology is the basis of understanding the olfactory system information coding mechanism. The olfactory bulb on the olfactory bulb contains many complex micronetworks which perform many different operations on olfactory information input. It plays an important role in the processing of olfactory information. Perigloboid cells are important intermediate neurons involved in the loop of olfactory pellets. Their functions in olfactory information processing still need to be studied. There are many subtypes in peribulbar cells, and different subclasses have different functions. One of the subclasses distributes the plateau potential under stimulation. The cells around the globus have the ability to convert the high-frequency inputs of the axons of the olfactory sensory neurons into low-frequency outputs. It is very likely that these cells are involved in the timing pattern of olfactory pellet activity, which is gradually attracting attention. In this paper, we have established a cell that contains the platform-type periglobule. The model of olfactory pellet network with synaptic connection between mitral cells and cells provides a platform for studying the role of olfactory globule loop in olfactory information coding. The role of peripheral cells in the network of olfactory pellets was preliminarily analyzed. In this paper, the mechanism of olfactory production and the anatomical structure of olfactory bulb are briefly introduced, and the research status of olfactory bulb and its model are introduced in detail, and the physiological characteristics and modeling progress of peripheral cells are also introduced. Secondly, the neuron cable model, ion channel dynamics model, synaptic dynamics model and modeling tool software are introduced in detail. Thirdly, the various cell models and the parameters of synaptic models are introduced, and the topology of the network is also introduced. Finally, on the basis of the network model, the role of the pericyclic cells in the platform-phase was preliminarily analyzed. It is found that the peripheral cells of the platform-shaped sphere synchronize with the peak emitter of the mitral cells projected into the same olfactory pellet. The electrophysiological network model of olfactory pellets established in this paper provides a good platform for the theoretical research of olfactory nervous system coding. It lays a good foundation for the further study of olfactory nervous system coding theory.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R338

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