可兴奋细胞胞吐胞吞的耦联机制

发布时间：2018-01-15 22:11

本文关键词：可兴奋细胞胞吐胞吞的耦联机制　出处：《中国细胞生物学学报》2015年12期 　论文类型：期刊论文

【摘要】：调节型胞吐存在于神经元、内分泌细胞和外分泌细胞等可兴奋细胞以及免疫细胞等特化细胞中,是复杂而精确调节的分泌过程。其作用广泛,与神经信号传递、激素释放、免疫反应等重要的生理活动密切相关。调节型胞吐发生后,在分秒的时间尺度上,可兴奋性细胞快速启动与胞吐发生位置密切相关的调控型胞吞,回收细胞膜脂质和囊泡的膜蛋白,迅速清除分泌位点上由于胞吐而留下的蛋白以利于下一轮的分泌,回收并填充可释放囊泡库,维持细胞膜的平衡。该文先分别介绍可兴奋细胞中胞吐和胞吞的主要模式,然后探讨了它们之间耦联的机制。
[Abstract]:Modulatory exocytosis exists in excitable cells such as neurons, endocrine cells and exocrine cells, as well as specialized cells such as immune cells. It is a complex and precise regulation of secretion process. Hormone release, immune response and other important physiological activities are closely related. After modulating exocytosis, on the time scale of minute second, the excitatory cells can quickly start the regulated cytoplasm closely related to the location of exocytosis. Cell membrane lipids and membrane proteins of vesicles were recovered, and the proteins left by exocytosis at the secretory sites were quickly cleared to facilitate the next round of secretion. The vesicles could be released by recycling and filling in the vesicles. In order to maintain the balance of cell membrane, the main patterns of exocytosis and endocytosis in excitable cells were introduced, and the mechanism of coupling between them was discussed.
【作者单位】：生物膜与膜生物工程国家重点实验室北京大学分子医学研究所;
【基金】：国家重点基础研究发展计划(批准号:2013CB531200) 国家自然科学基金(批准号:81222020;31221002;31327901;31570839和31301186)资助的课题~~
【分类号】：R3416
【正文快照】： 细胞内待分泌的生物分子包裹在脂质双层膜组成的囊泡中,移动到细胞膜附近,通过囊泡膜与细胞膜融合而排出细胞外的过程,叫做胞吐。细胞胞吐有组成型(constitutive)和调节型(regulative)两种[1]。所有的真核细胞都存在组成型胞吐,其分泌不受外界刺激的调节,主要作用是更新细胞质

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