五行音乐联合理虚解郁方对慢性疲劳综合征大鼠模型的行为学影响

发布时间：2018-03-04 03:20

本文选题：理虚解郁方　切入点：五行音乐　出处：《辽宁中医杂志》2015年08期 　论文类型：期刊论文

【摘要】：目的:观察五行音乐联合中药理虚解郁方对慢性疲劳综合征大鼠行为学的影响。方法:将清洁级SD雄性大鼠78只随机分为正常对照组、模型组、理虚解郁方组、音乐组(按五行音乐:宫商角徵羽五调分为5组),中药联合音乐治疗组(按五行音乐:宫商角徵羽五调分为5组,简称音药组)每组6只。给予复合因素造模(慢性束缚、冷水游泳、夹尾激怒法),同时正常组、模型组予生理盐水2 m L,理虚解郁方组及音药组予中药2 m L灌胃,音乐及音药组同时接受五行音乐治疗,连续30 d,观察治疗前后大鼠行为学(旷场实验、鼠尾悬挂实验、力竭游泳实验)的变化。结果:1与正常组比较,模型组大鼠穿格次数、直立次数、挣扎次数减少,静止时间延长,力竭游泳时间明显缩短,差异有统计学意义(P0.05);2与模型组比较,中药组力竭游泳时间明显延长,挣扎次数、直立次数、穿格次数增加,静止时间缩短,其差异均有统计学差异(P0.05)。各音乐组力竭游泳时间明显延长;且角调组挣扎次数增加、静止时间缩短,其差异有统计学意义(P0.05);各音药组力竭游泳时间明显延长,药徵组直立次数、穿格次数、挣扎次数均增加,静止时间缩短;药角组穿格次数、及挣扎次数增加,药宫组穿格次数增加,药商组静止时间缩短,药羽组穿格次数、挣扎次数均增加,静止时间缩短,差异均有统计学意义;3各组间比较,中药组穿格次数较药宫组、药商组、药羽组增加;药角组、药徵组较其对应单纯音乐组穿格次数增加,药徵组直立次数增加,其差异有统计学意义。结论:五行音乐联合中药理虚解郁方对于缓解大鼠的躯体及精神疲劳有较为明显的疗效,角调、徵调提示有初步增效作用。
[Abstract]:Objective: to observe the effect of the combination of five elements of music on the behavior of rats with chronic fatigue syndrome. Methods: 78 SD male rats of clean grade were randomly divided into normal control group, model group and Li-deficiency Jieyu prescription group. The music group was divided into 5 groups according to the five elements music: gong Shang angle syndrome five tones, and the traditional Chinese medicine combined music treatment group (according to the five elements music: gong Shang angle feather five tones divided into 5 groups, abbreviated as the tone medicine group), each group had 6 rats in each group. Cold water swimming, tail irritation method, normal group, model group, normal saline 2 mL, lixiu Jiayu prescription group and phonetic medicine group were given 2 mL of traditional Chinese medicine, and music and tone medicine group were treated with five elements music at the same time. After 30 days of treatment, the changes of behavior (open field test, tail suspension test, exhaustive swimming test) were observed. Results compared with the normal group, the rats in the model group decreased the number of lattice piercing, the number of upright, and the times of struggle. Compared with the model group, the swimming time of the traditional Chinese medicine group was significantly prolonged, the times of struggle, the number of upright, the number of piercing increased, and the time of rest was shortened, compared with the model group, the time of swimming was prolonged, the time of exhaustive swimming was shortened, and the time of exhaustive swimming was obviously shortened, compared with the model group. All the differences were statistically significant (P 0.05). The time of exhaustive swimming was significantly prolonged in each music group, and the number of struggle increased and the rest time was shortened in the angle adjustment group, the difference was statistically significant (P 0.05), the swimming time of exhausted swimming in each sound medicine group was obviously prolonged, and the times of standing upright in the drug sign group were obviously prolonged. The number of piercing, the number of struggles and the number of struggles in the drug angle group increased, the rest time in the drug quotient group decreased, and the number of cases and struggles increased in the drug plume group, while the number of cases in the drug angle group and the number of struggles in the drug angle group increased, and the rest time of the drug quotient group decreased. The rest time was shortened, the difference was statistically significant. The number of cases in the Chinese medicine group was higher than that in the medicine palace group, the drug quotient group, the drug plume group, the drug angle group, the drug sign group, and the corresponding music group, and the number of cases in the traditional Chinese medicine group was higher than that in the corresponding pure music group. Conclusion: the combination of five elements music has obvious curative effect on relieving the physical and mental fatigue of rats. The angle adjustment and sign indicate that there is a preliminary synergistic effect.
【作者单位】：上海中医药大学附属岳阳中西医结合医院中医内科;上海中医药大学;
【基金】：国家自然科学基金面上项目(81173227) 上海市卫生局项目(30304115240) 国家中医药管理局十二五重点学科“治未病学科”项目上海市三年中医行动计划项目(ZYSNXD-YL-CTXK) 岳阳医院慢性疲劳综合征重点专科建设项目
【分类号】：R285.5;R-332

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