流感病毒在脂筏上组装与出芽

发布时间：2018-03-22 22:37

本文选题：流感病毒　切入点：脂筏　出处：《生物化学与生物物理进展》2015年06期 　论文类型：期刊论文

【摘要】：流感病毒造成的季节性流行性疾病给全世界带来沉重的健康负担.近年来,甲型流感病毒的变种H5N1、H7N9给各国带来了很大危害.流感病毒属于正黏附病毒科,它的遗传物质由多个节段的负链RNA组成,其组装和出芽剪切生殖是一个涉及到多种病毒因子,多步骤、复杂的生化过程.流感病毒会使用宿主的细胞膜上的"脂筏"区域作为病毒出芽位点.首先病毒的两种糖蛋白NA蛋白、HA蛋白会在脂筏区域聚集,造成脂筏区膜变形弯曲,并且发动出芽的过程.接着,流感病毒基质蛋白M1的C端与HA、NA结合,其自身在脂筏区域开始多聚化并使膜向外弯曲形成原始病毒体的内部结构,接着招募病毒的核糖核蛋白复合物(VRNP)与M2蛋白,使组装的过程进一步完成.最后,M2蛋白会富集在原始病毒体的底部,完成膜的剪切和病毒体的释放.
[Abstract]:The seasonal epidemic caused by influenza viruses imposes a heavy health burden on the whole world. In recent years, the variant of influenza A virus H 5N 1, H 7N 9, has brought great harm to all countries. The influenza virus belongs to the positive Adhesion virus family. Its genetic material is composed of negative strands of multiple segments of RNA, and its assembly and budding and shearing reproduction are a multistep process involving a variety of viral factors. Complex biochemical processes. Influenza viruses use the "lipid raft" region of the host's cell membrane as the budding site. First, the HA protein, the two glycoproteins of the virus, aggregates in the lipid raft region, causing the membrane to deform and bend. Then the C end of the influenza virus matrix protein M1 binds to HANNA, which begins to polymerize in the lipid raft region and bend the membrane outward to form the internal structure of the primitive virus. Then the viral ribonucleoprotein complex (VRNPN) and M2 protein were recruited to further complete the assembly process. Finally, the M2 protein was enriched at the bottom of the primordial virus, and the membrane shearing and the release of the virus body were completed.
【作者单位】：中国科学院合肥物质科学研究院强磁场科学中心;
【基金】：国家自然科学基金资助项目(5049696)~~
【分类号】：R373

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