小肠胆固醇吸收相关蛋白的研究进展

发布时间：2018-05-23 23:45

本文选题：小肠 + 胆固醇　；参考：《军事医学》2015年06期

【摘要】：多种蛋白参与了小肠胆固醇的吸收,其中尼曼-匹克C1型类似蛋白1(Niemann-Pick C1 like 1,NPC1L1)主要介导小肠对胆固醇的吸收;小肠吸收的游离胆固醇在酰基辅酶A-胆固醇酰基转移酶2[acyl-coenzyme A(Co A)∶cholesterol acyltransferase 2,ACAT2]的催化下形成胆固醇酯并经淋巴系统进入血液循环,而未被酯化的胆固醇则通过ATP结合盒转运蛋白G5/G8[ATP-binding cassette(ABC)transporters G5/G8,ABCG5/ABCG8]分泌入肠腔,转录因子肝X受体(liver X receptor,LXR)在小肠胆固醇吸收过程中发挥了重要的调节作用。该文主要对小肠胆固醇吸收相关蛋白NPC1L1、ABCG5/ABCG8、ACAT2和LXR的研究进展进行了综述。
[Abstract]:A variety of proteins are involved in the absorption of cholesterol in the small intestine, among which 1(Niemann-Pick C1 like 1 / NPC1L1) mainly mediates the absorption of cholesterol in the small intestine. The free cholesterol absorbed by the small intestine is catalyzed by acyl coenzyme A- cholesterol acyltransferase 2 [acyl-coenzyme A(Co A):cholesterol acyltransferase _ 2 ACA _ T2] to form cholesterol ester and enter the blood circulation through the lymphatic system. The unesterified cholesterol was secreted into the intestinal cavity through the ATP binding cassette transporter G5/G8 [ATP-binding cassette(ABC)transporters G5 / G8 ABCG5 / ABCG8]. The transcription factor liver X receptor LXR played an important role in the absorption of cholesterol in the small intestine. This paper reviews the advances in the studies of small intestinal cholesterol absorption-associated protein (NPC1L1) ABCG5 / ABCG8 ACAT2 and LXR.
【作者单位】：军事医学科学院基础医学研究所;中国航天员科研训练中心;
【基金】：国家科技重大专项新药创制课题资助项目(2012ZX09102301-017) 国家重大新药创制生物技术大平台资助项目(2012ZX09301003-001-005-026)
【分类号】：R333

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