颈椎后凸畸形动物模型构建及其相关研究
发布时间：2018-07-14 15:32
【摘要】： 目的颈椎后凸畸形模型的构建及其相关研究。方法采用椎板切除等方法构建颈椎后凸畸形的动物模型,对模型行生物力学、影像学测量、超微结构观察研究,同时对颈椎后凸畸形的患者行影像学测量和临床研究。结果1实验组在4～6月后形成了后凸畸形。2后凸节段多发生在C2—C5节段;后凸畸形节段屈伸运动范围明显减小。3实验组羊的ROM明显小于正常组,弯曲刚度明显大于正常组。4实验羊颈椎软骨终板有明显细胞和基质受损现象。5提供颈椎体在失状状面上的空间位置的数据;C/M比值评价脊髓受压明显优于C/F比值;颈椎后凸畸形畸形程度、脊髓压迫程度和临床表现有明显的相关性。6总结颈椎后凸畸形特有的临床特征,制定出个性化的治疗方案,患者取得了较好的疗效。结论1成功构建出颈椎后凸畸形的动物模型,提供一有效的研究载体。2颈椎后凸畸形的后凸节段僵硬,后凸节段多集中在C2—5节段。3后凸畸形颈椎的ROM的减小,弯曲刚度增加和关节面不平整。4颈椎后凸畸形椎体的软骨终板生长受到抑制,颈椎前部短缩。5为颈椎后凸畸形矫正提供椎体正常空间位置数据;C/M比值是临床评估颈脊髓疾病的良好标准之一;当后凸节段后切线夹角为20°和C/M比值小于0.338时出现临床症状,需治疗干预。6颈椎后凸畸形患者有其特有的临床特征,对于每一位患者要制定出个性化的治疗策略。
[Abstract]:Objective to construct a cervical kyphosis model and its related research. Methods the animal model of cervical kyphosis was established by laminectomy. Biomechanics, imaging measurement, ultrastructure observation were performed on the model, and the imaging and clinical studies were performed on the patients with cervical kyphosis. Results 1 from 4 to 6 months after the formation of kyphosis in experimental group, 2 kyphosis segment occurred mostly in C2-C5 segment, and the range of flexion and extension of kyphosis segment in experimental group was significantly smaller than that in normal group, and the range of flexion and extension of kyphosis segment in experimental group was obviously smaller than that in normal group. The bending stiffness was significantly higher than that in the normal group (group .4). The damage of cervical cartilage endplate cells and matrix provided data on the spatial position of cervical vertebrae on the lost plane. The ratio of C / M to C / M was superior to that of C / F ratio in evaluating spinal cord compression. The degree of cervical kyphosis, the degree of spinal cord compression and the clinical manifestation were significantly correlated. 6. The clinical features of cervical kyphosis were summarized, and the individualized treatment scheme was worked out. Conclusion 1 the animal model of cervical kyphosis was successfully constructed, which provided an effective research carrier for the kyphosis segment stiffness of cervical kyphosis. The kyphosis segment was mostly concentrated on the reduction of ROM in C2-5 segment .3 kyphosis. Increased bending stiffness and uneven articular facet. 4 the growth of cartilage endplate in cervical kyphosis was inhibited. The C / M ratio is one of the good criteria for the clinical evaluation of cervical spinal cord diseases, when the angle of the posterior tangent of the kyphosis segment is 20 掳and the ratio of C / M is less than 0.338, the clinical symptoms appear. The patients with cervical kyphosis need treatment and intervention.
【学位授予单位】：第二军医大学
【学位级别】：博士
【学位授予年份】：2008
【分类号】：R682;R-332
本文编号：2122100
[Abstract]:Objective to construct a cervical kyphosis model and its related research. Methods the animal model of cervical kyphosis was established by laminectomy. Biomechanics, imaging measurement, ultrastructure observation were performed on the model, and the imaging and clinical studies were performed on the patients with cervical kyphosis. Results 1 from 4 to 6 months after the formation of kyphosis in experimental group, 2 kyphosis segment occurred mostly in C2-C5 segment, and the range of flexion and extension of kyphosis segment in experimental group was significantly smaller than that in normal group, and the range of flexion and extension of kyphosis segment in experimental group was obviously smaller than that in normal group. The bending stiffness was significantly higher than that in the normal group (group .4). The damage of cervical cartilage endplate cells and matrix provided data on the spatial position of cervical vertebrae on the lost plane. The ratio of C / M to C / M was superior to that of C / F ratio in evaluating spinal cord compression. The degree of cervical kyphosis, the degree of spinal cord compression and the clinical manifestation were significantly correlated. 6. The clinical features of cervical kyphosis were summarized, and the individualized treatment scheme was worked out. Conclusion 1 the animal model of cervical kyphosis was successfully constructed, which provided an effective research carrier for the kyphosis segment stiffness of cervical kyphosis. The kyphosis segment was mostly concentrated on the reduction of ROM in C2-5 segment .3 kyphosis. Increased bending stiffness and uneven articular facet. 4 the growth of cartilage endplate in cervical kyphosis was inhibited. The C / M ratio is one of the good criteria for the clinical evaluation of cervical spinal cord diseases, when the angle of the posterior tangent of the kyphosis segment is 20 掳and the ratio of C / M is less than 0.338, the clinical symptoms appear. The patients with cervical kyphosis need treatment and intervention.
【学位授予单位】：第二军医大学
【学位级别】：博士
【学位授予年份】：2008
【分类号】：R682;R-332
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