内毒素耐受形成过程中TLRs信号通路的作用及其调控

发布时间：2018-08-28 06:06

【摘要】：内毒素耐受是指脂多糖(LPS)刺激后,机体或细胞对后续刺激反应性降低的一种现象。Toll样受体(TLR)参与了LPS信号的跨膜转导。TLRs信号转导通路在内毒素耐受发生中发挥了重要作用,其通过改变信号蛋白和下游细胞因子的结构和功能,导致炎性因子释放减少。丝裂原活化蛋白激酶(MAPKs)及IL-1受体相关激酶(IRAK)家族成员、细胞膜表面的清道夫受体SR-A、TLR4同源体RP-105、细胞因子信号抑制物(SOCS)等均可参与TLRs信号转导通路的调控。miRNA作为小分子非编码RNA,通过作用于炎症信号传导通路调控内毒素耐受的发生发展,同时可调控免疫反应和炎性因子表达。关于miRNA在内毒素耐受调控中的作用的研究较多。在TLRs信号转导通路中产生调控作用的miRNA主要有miRNA-155、miRNA-146、miRNA-98、miRNA-125b和let-7e,具体作用机制有待进一步探索。
[Abstract]:Endotoxin tolerance is a phenomenon in which the response of body or cell to subsequent stimulation decreases after stimulation by lipopolysaccharide (LPS). Toll-like receptor (TLR) is involved in the transmembrane transduction of LPS signal. TLRs signal transduction pathway plays an important role in the development of endotoxin tolerance. By changing the structure and function of signal proteins and downstream cytokines, it reduces the release of inflammatory factors. Members of the (IRAK) family of mitogen-activated protein kinase (MAPKs) and IL-1 receptor-associated kinase (IRAK), The scavenger receptor SR-A,TLR4 homologue on cell membrane surface, RP-105, cytokine signal inhibitor (SOCS), can be involved in the regulation of TLRs signal transduction pathway. MiRNA acts as a small molecule non-coding RNA, to regulate the development of endotoxin tolerance by acting on inflammatory signal transduction pathway. It can also regulate the immune response and the expression of inflammatory factors. There are many studies on the role of miRNA in the regulation of endotoxin tolerance. The specific mechanisms of miRNA-155,miRNA-146,miRNA-98,miRNA-125b and let-7e, in the regulation of miRNA in TLRs signal transduction pathway need to be further explored.
【作者单位】：成都医学院第一附属医院;
【基金】：国家自然科学基金面上项目(30672175) 四川省教育厅重点项目(09ZA018)
【分类号】：R363

【共引文献】