健脾益肺化痰方对慢性阻塞性肺疾病模型大鼠肺功能及血气的影响

发布时间：2019-05-23 19:51

【摘要】：目的探讨健脾益肺化痰方对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)模型大鼠肺功能及血气的影响。方法 60只Wistar雄性大鼠随机分为正常对照组、模型对照组、健脾益肺方组、化痰方组、健脾益肺化痰方组和羧甲司坦组,每组10只。除正常组外,其他各组采用单纯香烟烟熏法建立COPD大鼠模型。健脾益肺方组、化痰方组、健脾益肺化痰方组和羧甲司坦组大鼠分别给予相应的药物灌胃治疗,模型组和正常组给予等体积的纯净水。末次给药后,禁食12 h,对各组进行肺功能及动脉血气分析。结果与正常对照组相比,模型对照组大鼠肺功能标准指标FEV_(0.3)/FVC及动脉血酸碱度(p H)、氧分压(Pa O_2)、氧饱和度(Sa O_2)均降低(P0.05),二氧化碳分压(Pa CO_2)升高(P0.05)。与模型对照组比较,健脾益肺方组、化痰方组、健脾益肺化痰方组的肺功能及血气分析检测指标出现不同程度改善(P0.05)。其中,与健脾益肺组(治本组)、化痰组(治标组)比较,健脾益肺化痰方组(标本兼治组)肺功能及血气分析进一步改善。结论健脾益肺化痰系列方可以有效改善COPD大鼠肺功能及动脉血气,其机制可能是通过"化痰"作用,抑制了杯状细胞化生及黏液高分泌,使气道分泌物减少,阻力降低,呼吸及动脉血流通畅。其中,健脾益肺化痰方对COPD大鼠肺功能及动脉血气改善较明显,这可能与其标本兼治"痰"的作用有关。
[Abstract]:Objective to investigate the effect of Jianpi Yifei Huatan recipe on pulmonary function and blood gas in rats with chronic obstructive pulmonary disease (chronic obstructive pulmonary disease,COPD). Methods Sixty male Wistar rats were randomly divided into normal control group, model control group, Jianpi Yifei recipe group, Huatan recipe group, Jianpi Yifei Huatan recipe group and Carboxychastan group with 10 rats in each group. In addition to the normal group, the COPD rat model was established by cigarette fumigation in other groups. The rats in Jianpi Yifei recipe group, Huatan recipe group, Jianpi Yifei Huatan recipe group and Carboxymethylastan group were treated with the corresponding drugs intragastrically, respectively. The model group and the normal group were given the same volume of pure water. After the last administration, pulmonary function and arterial blood gas were analyzed after fasting for 12 hours. Results compared with the normal control group, the standard indexes of pulmonary function FEV_ (0.3) / FVC, arterial pH (p H), oxygen partial pressure (Pa O 鈮，

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