血小板在炎性疾病中活化机制研究进展

发布时间：2017-12-28 09:28

本文关键词：血小板在炎性疾病中活化机制研究进展　出处：《天津医药》2015年10期 　论文类型：期刊论文

【摘要】：血小板是具有止血功能的血细胞成分,也是炎性病变的重要参与者。研究发现,在脓毒症时,血小板对白细胞募集能力的增强及与之形成聚集体是促进炎性病变的重要因素,而血小板数量减少往往与不良临床结局有关。因此,血小板试验在病情监测中的价值成为研究者们关注的问题。在侵入性真菌感染时,血小板同时表达介导抑菌效应和促进真菌传播效应,从而使调控血小板和真菌之间相互作用变得困难。在过敏性炎症时,血小板的过度活化可加重气道障碍并导致肺功能改变。本文就血小板在炎性病变中活化机制的研究进展进行综述。
[Abstract]:Platelet is a blood cell component with hemostasis, and it is also an important participant in inflammatory lesions. It is found that in sepsis, the enhancement of leukocyte recruitment ability by platelet and the formation of aggregates are important factors to promote inflammatory diseases, and the decrease of platelets is often associated with adverse clinical outcomes. Therefore, the value of platelet test in the monitoring of the condition of the disease has become a concern of the researchers. In invasive fungal infection, simultaneous expression of platelets mediates bacteriostatic effect and promotes fungal transmission, making it difficult to regulate the interaction between platelets and fungi. In allergic inflammation, excessive activation of platelets can aggravate airway disorders and lead to changes in lung function. This article reviews the research progress on the activation mechanism of platelets in inflammatory lesions.
【作者单位】：天津医科大学总医院耳鼻喉科;天津医科大学总医院医学检验科;
【基金】：天津市卫生行业重点攻关项目(12KG131)
【分类号】：R363
【正文快照】： 血小板是循环血液中的主要细胞成分,在血管损伤时可通过黏附聚集于受损部位完成一级止血过程,以避免血液丢失。在病理情况下,异常活化的血小板可增加血栓栓塞的风险[1]。临床研究发现,作为血液中数量最多的具有免疫功能的细胞,血小板在机体对病原体防御过程中也起重要作用[2]

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