微炎症反应状态与钙化

发布时间：2018-09-09 11:53

【摘要】：背景:近年来,矿化物在异常部位的沉积所形成的病理性钙化如血管钙化,已成为促进多种疾病发生发展的病理基础和危险因素,且广泛的研究认为微炎症反应状态与病理性钙化密切相关。目的:就微炎症反应状态时体内的炎症相关指标与钙化相关因子的关系来对微炎症反应状态和钙化的关系做进一步的概述和总结。方法:应用计算机检索中国知网,万方数据库以及PubMed数据库2000年1月至2015年1月有关微炎症反应状态和钙化关系方面的文献,中文检索词"钙化、微炎症反应状态、炎症因子",英文检索词"The mechanism of calcification、Micro-inflammatory state、Inflammatory factor"。结果与结论:微炎症反应状态是一种由非病原微生物感染引起的非显性炎症状态,表现为全身循环中炎性蛋白、炎症性细胞因子低水平、持续的升高。目前以前炎症细胞因子白细胞介素1、白细胞介素6、白细胞介素8、肿瘤坏死因α以及急性时相反应蛋白C-反应蛋白作为检测微炎症反应状态的客观、敏感的有效指标。且大量研究已经发现,体内轻度升高的白细胞介素1、白细胞介素6、白细胞介素8、肿瘤坏死因α及C-反应蛋白与促钙化因子呈正相关关系,从而说明微炎症状态具有促进钙化的作用。
[Abstract]:Background: in recent years, pathological calcification, such as vascular calcification, caused by the deposition of mineralized materials in abnormal areas, has become the pathological basis and risk factor to promote the occurrence and development of many diseases. And it is widely believed that the microinflammatory response is closely related to pathological calcification. Aim: to summarize the relationship between microinflammatory response and calcification related factors. Methods: to search the literatures on microinflammatory response state and calcification relationship between January 2000 and January 2015 in China Zhiwang, Wanfang database and PubMed database. The Chinese key words were "calcification, microinflammatory response state", and the Chinese key words were "calcification, microinflammatory response state". Inflammatory factor ", English key word" The mechanism of calcification,Micro-inflammatory state,Inflammatory factor ". Results & conclusion: the microinflammatory response is a non-dominant inflammatory state caused by non-pathogenic microorganism infection, which is characterized by a low level of inflammatory cytokines in systemic circulation and a continuous increase in inflammatory cytokines. At present, inflammatory cytokines interleukin 1, interleukin 6, interleukin 8, tumor necrosis factor 伪 and acute phase reactive protein C reactive protein are used as objective and sensitive indicators for the detection of microinflammatory reaction. A large number of studies have found that slightly elevated interleukin-1, interleukin-6, interleukin-8, tumor necrosis due to 伪 and C-reactive protein are positively correlated with calcifying factors. Therefore, the microinflammatory state has the function of promoting calcification.
【作者单位】：武汉大学人民医院心内科;
【分类号】：R364.5

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