胃食管反流病动物模型在中医研究中的应用

发布时间：2018-12-27 06:29

【摘要】：胃食管反流病是消化系统常见难治病种,其症状多样反复、病机复杂未明,相关临床研究和动物实验都是中西医研究的热点和难点。目前,其模型制作多涉及手术造模、食管气囊扩张制备、酸性物质和胃蛋白酶建立三种形式。中医治疗胃食管反流病多有特点,证型分类多元,针对难治性胃食管反流病常常有出奇制胜的效果;单纯运用西医造模方法进行中医研究,不符合中医辨证论治的理论基础和临床运用的实际情况。中医研究应根据实验要求和目的,制备符合疾病特性的合理造模方式,并强调探索病证结合的动物模型。当前情况下,探索病证结合动物模型的工作刚刚开始,得到推广较少,缺乏共识性评价体系;如何提高模型成功率、降低成本和大鼠死亡率成为下一步研究的重点方向。
[Abstract]:Gastroesophageal reflux disease (GERD) is a common refractory disease in the digestive system. The symptoms of gastroesophageal reflux disease are various and repeated, the pathogenesis is complicated, and the related clinical studies and animal experiments are the hot and difficult points in the research of TCM and Western medicine. At present, most of the models are made by operation, dilatation of esophagus sac, establishment of acid substance and pepsin. Traditional Chinese medicine treatment of gastroesophageal reflux disease has more characteristics, multiple classification of syndromes, difficult gastroesophageal reflux disease often has the effect of outlandish victory; It is not in accordance with the theoretical basis of TCM differentiation and treatment and the actual situation of clinical application to use the method of model making in western medicine. According to the requirements and objectives of the experiment, the research of traditional Chinese medicine (TCM) should make a reasonable model according to the characteristics of the disease, and emphasize the exploration of the animal model of the combination of disease and syndromes. At present, the work of exploring animal models combining disease and syndrome has just begun, which has been less popularized, and lack of consensus evaluation system. How to improve the success rate of the model, reduce the cost and rat mortality become the focus of the next research direction.
【作者单位】：北京中医药大学东直门医院(第一临床医学院);中国中医科学院望京医院;
【基金】：中国中医科学院基本科研业务费自主选题项目(ZZ0708091)
【分类号】：R571;R-332

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